L-theanine helps you feel balanced, calm and confident--without making you too sleepy to go about your daily routine. You can think of L-theanine as a naturally mild tranquilizer.

Valerian extract is another important compound found in Somadin which is very effective in treating anxiety and stress. Valerian has long been used to treat insomnia, phobias, epilepsy, menstrual cramps and anxiety attacks. Valerenic acid, one of the active compounds in Valerian extract, is believed to simultaneously cause GABA to be released from the nerve endings in the brain while inhibiting enzymes from destroying GABA.

This results in a pleasant sedative effect.

Read about L-Theanine

Read about Valerian Extract

Read about B-Vitamins

Read about Glutamine

Valerian extract:

Relaxing effects of Valeriana officinalis extracts on isolated human non-pregnant uterine muscle.
Occhiuto F, Pino A, Palumbo DR, Samperi S, De Pasquale R, Sturlese E, Circosta C.
J Pharm Pharmacol. 2009 Feb;61(2):251-6.

GABA A receptors as in vivo substrate for the anxiolytic action of valerenic acid, a major constituent of valerian root extracts.
Benke D, Barberis A, Kopp S, Altmann KH, Schubiger M, Vogt KE, Rudolph U, Möhler H.
Neuropharmacology. 2009 Jan;56(1):174-81. Epub 2008 Jun 17.
PMID: 18602406

Modulation of GABAA receptors by valerian extracts is related to the content of valerenic acid.
Trauner G, Khom S, Baburin I, Benedek B, Hering S, Kopp B.
Planta Med. 2008 Jan;74(1):19-24. Epub 2007 Dec 19.
PMID: 18095218

Initial exploratory observational pharmacology of Valeriana wallichii on stress management: a clinical report.
Bhattacharyya D, Jana U, Debnath PK, Sur TK.
Nepal Med Coll J. 2007 Mar;9(1):36-9.
PMID: 17593676

Oral nonprescription treatment for insomnia: an evaluation of products with limited evidence.
Meolie AL, Rosen C, Kristo D, Kohrman M, Gooneratne N, Aguillard RN, Fayle R, Troell R, Townsend D, Claman D, Hoban T, Mahowald M; Clinical Practice Review Committee; American Academy of Sleep Medicine.
J Clin Sleep Med. 2005 Apr 15;1(2):173-87. Review.
PMID: 17561634

Effect of valerian extract preparation (BIM) on the sleep-wake cycle in rats.
Tokunaga S, Takeda Y, Niimoto T, Nishida N, Kubo T, Ohno T, Matsuura Y, Kawahara Y, Shinomiya K, Kamei C.
Biol Pharm Bull. 2007 Feb;30(2):363-6.
PMID: 1726808

Valerian for sleep: a systematic review and meta-analysis.
Bent S, Padula A, Moore D, Patterson M, Mehling W.
Am J Med. 2006 Dec;119(12):1005-12. Review.
PMID: 17145239

Interaction of valerian extracts of different polarity with adenosine receptors: identification of isovaltrate as an inverse agonist at A1 receptors.
Lacher SK, Mayer R, Sichardt K, Nieber K, Müller CE.
Biochem Pharmacol. 2007 Jan 15;73(2):248-58. Epub 2006 Oct 6.
PMID: 17097622

A combination of valerian and lemon balm is effective in the treatment of restlessness and dyssomnia in children.
Müller SF, Klement S.
Phytomedicine. 2006 Jun;13(6):383-7. Epub 2006 Feb 17.
PMID: 16487692

Pharmacokinetics of valerenic acid after administration of valerian in healthy subjects.
Anderson GD, Elmer GW, Kantor ED, Templeton IE, Vitiello MV.
Phytother Res. 2005 Sep;19(9):801-3.
PMID: 16220575

Isobolographic analysis of the sedative interaction between six central nervous system depressant drugs and Valeriana edulis hydroalcoholic extract in mice.
Ugalde M, Reza V, González-Trujano ME, Avula B, Khan IA, Navarrete A.
J Pharm Pharmacol. 2005 May;57(5):631-9.
PMID: 15901352

L-theanine

The combined effects of L-theanine and caffeine on cognitive performance and mood.
Owen GN, Parnell H, De Bruin EA, Rycroft JA.
Nutr Neurosci. 2008 Aug;11(4):193-8.
PMID: 18681988

L-theanine, a natural constituent in tea, and its effect on mental state.
Nobre AC, Rao A, Owen GN.
Asia Pac J Clin Nutr. 2008;17 Suppl 1:167-8.
PMID: 18296328

Pharmacological modulation of cholinergic brain activity and its reflection in special EEG frequency ranges from various brain areas in the freely moving rat (Tele-Stereo-EEG).
Dimpfel W.
Eur Neuropsychopharmacol. 2005 Dec;15(6):673-82. Epub 2005 Jul 11.
PMID: 16009538

Effects of theanine, r-glutamylethylamide, on neurotransmitter release and its relationship with glutamic acid neurotransmission.
Yamada T, Terashima T, Okubo T, Juneja LR, Yokogoshi H.
Nutr Neurosci. 2005 Aug;8(4):219-26.
PMID: 16493792

Theanine, gamma-glutamylethylamide, a unique amino acid in tea leaves, modulates neurotransmitter concentrations in the brain striatum interstitium in conscious rats.
Yamada T, Terashima T, Kawano S, Furuno R, Okubo T, Juneja LR, Yokogoshi H.
Amino Acids. 2009 Jan;36(1):21-7. Epub 2008 Jan 15.
PMID: 18196445

Kimura K, Ozeki M, Juneja L, Ohira H (2007). "L-Theanine reduces psychological and physiological stress responses". Biol Psychol 74 (1): 39–45. doi:10.1016/j.biopsycho.2006.06.006. PMID 16930802.

Lu K, Gray M, Oliver C, Liley D, Harrison B, Bartholomeusz C, Phan K, Nathan P (2004). "The acute effects of L-theanine in comparison with alprazolam on anticipatory anxiety in humans". Hum Psychopharmacol 19 (7): 457–65. doi:10.1002/hup.611. PMID 15378679.
PMID: 19178774

B12 and B6

Folate, vitamin B12, homocysteine, and depressive symptoms in a population sample of older Chinese adults.
Ng TP, Feng L, Niti M, Kua EH, Yap KB.
J Am Geriatr Soc. 2009 May;57(5):871-6.
PMID: 19484842

Treament of depression: time to consider folic acid and vitamin B12.
Coppen A, Bolander-Gouaille C.
J Psychopharmacol. 2005 Jan;19(1):59-65. Review.
PMID: 15671130